AIM: To investigate the role of oxidative stress in regulating the functional expression of P-glycoprotein (P-gp) in mitochondria of D407 cells.METHODS: D407 cells were exposed to different ranges of concentrations of H2O2.The mitochondrial location of P-gp in the cells subjected to oxidative stress was detected Bag by confocal analysis.Expression
Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS).Histopathological and radiological analysis revealed that neurodegeneration occurs early in the disease course.However, the pathological mechanisms involved in neurodegeneration are poorly understood.Myelin oligodendrocyte glycoprotein (MOG)-ind
The article deals with Dryer Maintenance Kit the application of the ne bis in idem principle in the tax process.It focuses in particular on the nature of penalty payments under the Tax Code.The jurisprudence of the Supreme Courts of the Czech Republic and the European Court of Human Rights has recently raised more questions about it than gave answe
Abstract Background In recent years, the use of non- and semi-parametric models which estimate hazard ratios for analysing time-to-event outcomes is continuously criticized in terms of interpretation, technical implementation, and flexibility.Hazard ratios in particular are critically discussed for their misleading interpretation as relative risks